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PptT inhibitor 8918

CAS No. 65009-19-0

PptT inhibitor 8918 ( Compound 8918 )

Catalog No. M15469 CAS No. 65009-19-0

PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PptT inhibitor 8918
  • Note
    Research use only, not for human use.
  • Brief Description
    PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM).
  • Description
    PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM), shows an MIC90 of 3.1 uM against Mtb H37Rv; also exhibits MIC90s ranged from 0.56-3.0 uM (median 1.5 uM) against 29 clinical isolates of Mtb; inhibits growth of WT Mtb, but not of the pptT mutant W170S or WT Mtb expressing the pptT W170S mutant; kills Mycobacterium tuberculosis (Mtb) by binding and partially inhibiting PptT.
  • Synonyms
    Compound 8918
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    65009-19-0
  • Formula Weight
    262.36
  • Molecular Formula
    C14H22N4O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    Amidino-urea 1-[(2,6-diethylphenyl)-3-N-ethylcarbamimodoyl]urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ballinger E, et al. Science. 2019 Feb 1;363(6426). pii: eaau8959. doi: 10.1126/science.aau8959.
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