Home - Products - GPCR/G Protein - Antibacterial - PptT inhibitor 8918

PptT inhibitor 8918

CAS No. 65009-19-0

PptT inhibitor 8918 ( Compound 8918 )

Catalog No. M15469 CAS No. 65009-19-0

PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
100MG	Get Quote	Get Quote
200MG	Get Quote	Get Quote
500MG	Get Quote	Get Quote
1G	Get Quote	Get Quote

Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

PptT inhibitor 8918
Note

Research use only, not for human use.
Brief Description

PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM).
Description

PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM), shows an MIC90 of 3.1 uM against Mtb H37Rv; also exhibits MIC90s ranged from 0.56-3.0 uM (median 1.5 uM) against 29 clinical isolates of Mtb; inhibits growth of WT Mtb, but not of the pptT mutant W170S or WT Mtb expressing the pptT W170S mutant; kills Mycobacterium tuberculosis (Mtb) by binding and partially inhibiting PptT.
Synonyms

Compound 8918
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

Chemical Information

CAS Number

65009-19-0
Formula Weight

262.36
Molecular Formula

C14H22N4O
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

Amidino-urea 1-[(2,6-diethylphenyl)-3-N-ethylcarbamimodoyl]urea

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Ballinger E, et al. Science. 2019 Feb 1;363(6426). pii: eaau8959. doi: 10.1126/science.aau8959.

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

related products

Calcimycin

Calcimycin is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis.?It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria.?The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.?
Ozenoxacin

Ozenoxacin is a quinolone antibacterial. It shows potent activities against the main microorganisms isolated from soft tissue and skin infections.
DS-2969b

DS-2969b (DS 11960558) is a novel orally active GyrB inhibitor, inhibits the supercoiling activity of C. difficile DNA gyrase with IC50 of 20 ng/mL.

Sign In Join Free